On June 6, in the framework of St. Petersburg International Economic Forum, a session was held, titled "Russia-USA". Geopolitical turbulence, trade restrictions and economic sanctions continue to undermine trade and economic relations between the United States and Russia and hinder mutually beneficial investment cooperation. During this volatile period business has continued to evolve and has remained one of the few healthy areas of relations between the two countries. How are American investors evaluating the business climate and prospects for their business in Russia? What challenges have they faced and overcome when implementing projects in Russia? What is Russia’s role in the global value chain for the multinational today? What are the optimal models of relations in different sectors of the economy as seen by the companies today? Which are the most important sectors for the Russian companies to develop their business in the United States, which could contribute to the growth and stability of both economies?